The 5 Best Anti-Itch Creams

Whether your skin is ultradry, cracking, or infected, it can lead to uncomfortable itchiness that seems to have no end or relief in sight. Fortunately, the right anti-itch cream or hydrocortisone can provide fast, effective relief, so your skin will return to normal in no time.

What is anti-itch cream?

Anti-itch cream is a form of numbing medication that typically includes a small amount of hydrocortisone that can be applied to the skin topically. The over-the-counter cream can interfere with pain signals sent from the nerves to the brain to soothe inflamed, itchy skin.

Scratching an itch might temporarily ease the itching and uncomfortable symptoms, but in the end, it will just cause further irritation and prevent the skin from healing. Instead, use an anti-itch cream to ease the swelling, itching, redness, and pain associated with a range of minor skin irritations.

Top 5 anti-itch creams

Gold Bond Rapid Relief Anti-Itch Cream

The Gold Bond Rapid Relief Anti-Itch Cream is the #1 anti-itch cream on the market without a prescription, so you know it’s bound to work. The steroid and hydrocortisone-free cream is enriched with aloe, vitamin E, and menthol to provide cooling temporary relief of pain and itching in no time. The maximum strength medicated lotion provides skin protection and intensive, rapid healing for a range of itchy conditions, including minor skin irritations, minor cuts and scrapes, minor burns and sunburns, rashes, dry skin, poison ivy, oak, and sumac, and insect bites. It delivers fast acting relief that you can feel working even as you apply it.

Gold Bond has been a trusted provider of healing medicated creams since 1908. This cream provides twice the itch fighting medicines of any hydrocortisone formula, so you’ll get a better value and more relief for your money. This best-selling cream has outstanding reviews online and is recommended by GoodGuide. If you need more lotion for larger areas of the body, consider the best-selling Gold Bond Anti-Itch Lotion.

Currently $7.45 on Amazon

Cortizone-10 Max Strength Crème

As Amazon’s #1 best seller in cortisone treatments, the Cortizone-10 Max Strength Cortizone-10 Crème absorbs quickly to relieve itch almost immediately. It is enriched with aloe vera and vitamins A and E to help relieve burning, inflammation, redness, and itching, and to heal the wound naturally. The maximum-strength, healing formula is ideal for itchy skin, dry skin, eczema, skin irritations, rashes, burns and sunburns, insect bites, poison ivy, oak, and sumac, seborrheic dermatitis, and psoriasis.

This is the #1 doctor recommended itch medicine and is the strongest anti-itch cream you can get without a prescription. It is also one of the “most wished for” items on Amazon and has outstanding online reviews.

Currently $7.28 on Amazon

Neosporin Essentials Eczema Hydrocortisone Anti-Itch Cream

The Neosporin Essentials Eczema Hydrocortisone Anti-Itch Cream contains a dual-action formula that provides fast relief of itchy skin. The unique Relipid formula contains a lipid, humectant, emollient, and botanical blend, which can moisturize and restore your healthy skin. It can heal and offers fast relief of pain, inflammation, and itchy flare-ups due to eczema, insect bites, poison oak and ivy, seborrheic dermatitis, psoriasis, allergies, rashes, and minor skin irritations. The fragrance-free, antibiotic-free, maximum strength formula is clinically proven to improve dryness, flaking, and redness.

Neosporin has been a trusted family brand since 1954. Independent studies have shown that Neosporin is the #1 mom and doctor recommended brand because, over the years, they have designed products that really work. This anti-itch cream also received the Seal of Acceptance from the National Eczema Association, so you know it’s bound to work. In fact, many reviewers claim that this is a miracle in a bottle.

Currently $11.59 on Amazon

Aveeno Anti-Itch Concentrated Lotion

The Aveeno Anti-Itch Concentrated Lotion will stop the itching fast and will last for hours, so you can quickly enjoy the temporary relief of itching. This concentrated anti-itch lotion contains a triple oat complex to help provide relief from the itching and pain associated with eczema, dry skin, poison ivy, oak, and sumac, insect bites, allergies, chickenpox, rashes, and minor skin irritations. It also contains calamine to dry up any rashes or wounds to better protect the skin. The dermatologist-recommended lotion is soothing enough to be used on sensitive skin.

This is recommended by Total Beauty and has outstanding reviews online, with one of the highest GoodGuide ratings. It is also an Amazon best-seller and one of the “most wished for” items on Amazon.

Currently $6.62 on Amazon

Benadryl Extra Strength Itch Stopping Cream

The Benadryl Extra Strength Itch Stopping Cream is an antihistamine cream that protects your skin and provides lasting relief from itching. The skin protectant quickly relieves the pain and itching associated with insect bites, allergies, rashes, sunburns, minor burns, cuts, scrapes, skin irritations, and poison ivy, oak, and sumac. It can also help prevent further itching so your skin can heal faster.

This is an Amazon best-seller and has outstanding reviews online. It is a trusted family favorite and is also available in a cooling gel and stick form.

Currently $6.57 on Amazon

And those are our recommendations for the best anti-itch creams. As always, be sure to check Wise Bread's Buying Calendar to learn when and how to buy just about anything!

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The 5 Best Anti-Itch Creams

The 5 Best Anti-Itch Creams

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Guest's picture
Phil Mares

Never use these anti-itch creams on athlete's foot-type itches. You will need completely different medicine.